Op-brai140191 2578..2587

1 Centre for Neurodegenerative Disease Research, Institute on Aging and Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA 2 Department of Neurology, and Institute for Memory Impairments and Neurological Disorders, University of California at Irvine, Irvine, CA, USA 3 Department of Neurology, Department of Neurobiology and Behaviour, and Institute for Memory Impairments and Neurological Disorders, University of California at Irvine, Irvine, CA, USA